Healthy_back (healthy_back) wrote,
Healthy_back
healthy_back

Корь, MMR, аутизм

http://bez-privivok.livejournal.com/743427.html

Старший научный сотрудник Центра по контролю за заболеваниями США сначала анонимно, а затем, когда прошла утечка, официально признался, что результаты исследования 2004 г, которое является основным для опровержения связи между аутизмом и временем вакцинации MMR (корь-краснуха-паротит), были подделаны им и его соавторами.

В действительности исследование показало, в частности, что чернокожие мальчики, получившие MMR до двух лет, имели повышенный риск развития аутизма - называется цифра 340%.

Исследование Pediatrics. 2004 Feb;113(2):259-66.
Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan atlanta. (http://www.ncbi.nlm.nih.gov/pubmed/14754936)
DeStefano F1, Bhasin TK, Thompson WW, Yeargin-Allsopp M, Boyle C.

Сотрудника, которого замучала совесть, зовут Уильям Томпсон.

Обсуждение: http://eugenegp.livejournal.com/259764.html?thread=1872820#t1872820

CNN опубликовала репортаж на блогерском подсайте, потом удалила, потом после еще большего скандала, снова опубликовала, и добавила редакционную статью.
http://edition.cnn.com/2014/08/27/health/irpt-cdc-autism-vaccine-study/index.html

FOR IMMEDIATE RELEASE-AUGUST 27,2014

STATEMENT OF WILLIAM W. THOMPSON, Ph.D., REGARDING THE 2004 ARTICLE EXAMINING THE POSSIBILITY OF A RELATIONSHIP BETWEEN MMR VACCINE AND AUTISM

My name is William Thompson. I am a Senior Scientist with the Centers for Disease Control and Prevention, where I have worked since 1998.

I regret that my coauthors and I omitted statistically significant information in our 2004 article published in the journal Pediatrics. The omitted data suggested that African American males who received the MMR vaccine before age 36 months were at increased risk for autism. Decisions were made regarding which findings to report after the data were collected, and I believe that the final study protocol was not followed.

I want to be absolutely clear that I believe vaccines have saved and continue to save countless lives. I would never suggest that any parent avoid vaccinating children of any race. Vaccines prevent serious diseases, and the risks associated with their administration are vastly outweighed by their individual and societal benefits.

My concern has been the decision to omit relevant findings in a particular study for a particular sub­ group for a particular vaccine. There have always been recognized risks for vaccination and I believe it is the responsibility of the CDC to properly convey the risks associated with receipt of those vaccines.

I have had many discussions with Dr. Brian Hooker over the last 10 months regarding studies the CDC has carried out regarding vaccines and neurodevelopmental outcomes including autism spectrum disorders. I share his belief that CDC decision-making and analyses should be transparent. I was not, however, aware that he was recording any of our conversations, nor was I given any choice regarding whether my name would be made public or my voice would be put on the Internet.

I am grateful for the many supportive e-mails that I have received over the last several days. I will not be answering further questions at this time. I am providing information to Congressman William Posey, and of course will continue to cooperate with Congress. I have also offered to assist with reanalysis of the study data or development of further studies. For the time being, however, I am focused on my job and my family.

Reasonable scientists can and do differ in their interpretation of information. I will do everything I can to assist any unbiased and objective scientists inside or outside the CDC to analyze data collected by the CDC or other public organizations for the purpose of understanding whether vaccines are associated with an increased risk of autism. There are still more questions than answers, and I appreciate that so many families are looking for answers from the scientific community.

My colleagues and supervisors at the CDC have been entirely professional since this matter became public. In fact, I received a performance-based award after this story came out. I have experienced no pressure or retaliation and certainly was not escorted from the building, as some have stated.

Dr. Thompson is represented by Frederick M. Morgan,Jr., Morgan Verkamp, LLC, Cincinnati, Ohio, www.morganverkamp.com.

The debate over a link between autism and vaccines continues.

A study published earlier this month concluded African-American boys are more at risk for autism if they're given the measles, mumps and rubella vaccine before the age of 2. The study author says researchers at the Centers for Disease Control and Prevention knew about the link in 2004 -- and covered it up.

CDC researchers are standing by their original findings: that there is no link between autism and vaccination schedules.

The new study was funded by the Focus Autism Foundation, which says it is dedicated to exposing the causes of autism, "focusing on the role of vaccinations."

The study has since been removed from the public domain pending further investigation, according to Translational Neurodegeneration.

In an online statement, the scientific journal said the paper had been removed "because of serious concerns about the validity of its conclusions."

CNN first became aware of the study when an iReport was posted about its publication and the controversy surrounding it. iReport is CNN's user-generated news community.

Brian Hooker, author of the study and a biochemical engineer, found African-American boys who were given the MMR vaccine before age 24 months were more likely to be diagnosed with autism. To reach this conclusion, Hooker said he analyzed the same set of data that was the basis for a 2004 study done by researchers at the U.S. Centers for Disease Control and Prevention.

In 2004, scientists at the CDC's National Immunization Program published their study in the journal Pediatrics. Researchers compared 624 children with autism, age 3 to 10, with 1,824 developmentally healthy children. Most of the children, according to the study, were vaccinated between 12 and 17 months of age in accordance with vaccination recommendations.

The CDC study authors found no link between the age children were given their first MMR vaccination and autism diagnoses. Nor did they find a statistically significant increased risk for a particular racial group.

The CDC's raw data was made available for other scientists to use when its study was published in 2004. Hooker said he began his research after he was contacted by one of the original study authors, William Thompson, in November 2013. Thompson is a senior scientist with the CDC, where he has worked since 1998.

Hooker said he believes the increased risk for African-American boys he found was not identified in the CDC study because the researchers, including Thompson, deliberately limited the number of participants they included in their analysis, which he said altered the results. Hooker said that by excluding children without birth certificates, the CDC study results were skewed.

"I regret that my co-authors and I omitted statistically significant information in our 2004 article," Thompson said in a statement sent to CNN by his lawyer. "I have had many discussions with Dr. Brian Hooker over the last 10 months regarding studies the CDC has carried out regarding vaccines and neurodevelopmental outcomes, including autism spectrum disorders. I share his belief that CDC decision-making and analyses should be transparent."
However, Thompson went on to say that Hooker had recorded these conversations without his consent, and had posted them online without his knowledge.
In a statement to CNN on Monday, the CDC said its study presented results for two sets of children: all children initially recruited for the study, and a subset of children for whom a Georgia birth certificate was available.

"Access to the information on the birth certificates allowed researchers to assess more complete information on race, as well as other important characteristics," the CDC statement said.

Dr. Frank DeStefano, lead author of the 2004 study, said he and his colleagues stand by their findings. DeStefano said all the study authors, including Thompson, agreed on the analysis and interpretation before the study was submitted for publication 10 years ago. However, he said he plans to review his notes and will decide whether to run another analysis on the data.

The new study by Hooker has been publicized by groups like Focus Autism, which say vaccines have contributed to the "current autism epidemic and rise of chronic illness in children." Hooker is a scientific adviser for the Focus Autism Foundation. He also has a 16-year-old son with developmental delays who he said is "vaccine injured."


http://eugenegp.livejournal.com/263570.html
Associated Press выпустила репортаж о работе вакцинного суда (специальный орган, рассматривающий в США заявления от пострадавших от вакцинации, с выплатой из государственного фонда без обвинений в адрес фармкомпаний). За 25 лет выплачено около 3 млрд. долларов, но в целом говорят, что система работает плохо.
Государство все более осложняет получение компенсации, юристы, как водится, зарабатывают деньги. Рассмотрено более 14,5 тыс. случаев, из них 5 тыс. - суммарный иск по аутизму (отказано).

За вычетом аутизма, в первые 20 лет работы суда (1988-2007) врачи, представляющие правительство, рекомендовали выплату компенсации в 18% случаев, с 2008 по 2012 - всего в 5%. "Семь бывших правительственных чиновников признали в интервью, чтобы были сильно озабочены тем, что рассмотрение дел в вакцинном суде может снизить процент привитых."

http://www.oregonlive.com/today/index.ssf/2014/11/vaccine_court_attorneys_win_fa.html#incart_river

http://www.ncbi.nlm.nih.gov/pubmed/12145534
Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism.
Abstract
Autoimmunity to the central nervous system (CNS), especially to myelin basic protein (MBP), may play a causal role in autism, a neurodevelopmental disorder. Because many autistic children harbor elevated levels of measles antibodies, we conducted a serological study of measles-mumps-rubella (MMR) and MBP autoantibodies. Using serum samples of 125 autistic children and 92 control children, antibodies were assayed by ELISA or immunoblotting methods. ELISA analysis showed a significant increase in the level of MMR antibodies in autistic children. Immunoblotting analysis revealed the presence of an unusual MMR antibody in 75 of 125 (60%) autistic sera but not in control sera. This antibody specifically detected a protein of 73-75 kD of MMR. This protein band, as analyzed with monoclonal antibodies, was immunopositive for measles hemagglutinin (HA) protein but not for measles nucleoprotein and rubella or mumps viral proteins. Thus the MMR antibody in autistic sera detected measles HA protein, which is unique to the measles subunit of the vaccine. Furthermore, over 90% of MMR antibody-positive autistic sera were also positive for MBP autoantibodies, suggesting a strong association between MMR and CNS autoimmunity in autism. Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism.
Copyright 2002 National Science Council, ROC and S. Karger AG, Basel

http://www.ncbi.nlm.nih.gov/pubmed/21058170
Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002.
Abstract
Universal hepatitis B vaccination was recommended for U.S. newborns in 1991; however, safety findings are mixed. The association between hepatitis B vaccination of male neonates and parental report of autism diagnosis was determined. This cross-sectional study used weighted probability samples obtained from National Health Interview Survey 1997-2002 data sets. Vaccination status was determined from the vaccination record. Logistic regression was used to estimate the odds for autism diagnosis associated with neonatal hepatitis B vaccination among boys age 3-17 years, born before 1999, adjusted for race, maternal education, and two-parent household. Boys vaccinated as neonates had threefold greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. Non-Hispanic white boys were 64% less likely to have autism diagnosis relative to nonwhite boys. Findings suggest that U.S. male neonates vaccinated with the hepatitis B vaccine prior to 1999 (from vaccination record) had a threefold higher risk for parental report of autism diagnosis compared to boys not vaccinated as neonates during that same time period. Nonwhite boys bore a greater risk.

http://www.ncbi.nlm.nih.gov/pubmed/21993250
Hypothesis: conjugate vaccines may predispose children to autism spectrum disorders.
Abstract
The first conjugate vaccine was approved for use in the US in 1988 to protect infants and young children against the capsular bacteria Haemophilus influenzae type b (Hib). Since its introduction in the US, this vaccine has been approved in most developed countries, including Denmark and Israel where the vaccine was added to their national vaccine programs in 1993 and 1994, respectively. There have been marked increases in the reported prevalence of autism spectrum disorders (ASDs) among children in the US beginning with birth cohorts in the late 1980s and in Denmark and Israel starting approximately 4-5 years later. Although these increases may partly reflect ascertainment biases, an exogenous trigger could explain a significant portion of the reported increases in ASDs. It is hypothesized here that the introduction of the Hib conjugate vaccine in the US in 1988 and its subsequent introduction in Denmark and Israel could explain a substantial portion of the initial increases in ASDs in those countries. The continuation of the trend toward increased rates of ASDs could be further explained by increased usage of the vaccine, a change in 1990 in the recommended age of vaccination in the US from 15 to 2 months, increased immunogenicity of the vaccine through changes in its carrier protein, and the subsequent introduction of the conjugate vaccine for Streptococcus pneumoniae. Although conjugate vaccines have been highly effective in protecting infants and young children from the significant morbidity and mortality caused by Hib and S. pneumoniae, the potential effects of conjugate vaccines on neural development merit close examination. Conjugate vaccines fundamentally change the manner in which the immune systems of infants and young children function by deviating their immune responses to the targeted carbohydrate antigens from a state of hypo-responsiveness to a robust B2 B cell mediated response. This period of hypo-responsiveness to carbohydrate antigens coincides with the intense myelination process in infants and young children, and conjugate vaccines may have disrupted evolutionary forces that favored early brain development over the need to protect infants and young children from capsular bacteria.
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