Yaseen Galali1, and Hanee M Al-Dmoor
Camel milk reduces autism symptoms in children. Lactoferrin has ability to inhibit the proliferation of cancer cell. It has been reported that peptidoglycon recognition protein can role as anti-cancer activity against breast cancer through controlling metastasis.
Integr Cancer Ther. 2017 Dec; 16(4): 540–555. Published online 2016 Jun 23. doi: 10.1177/1534735416656051 PMCID: PMC5739131 PMID: 27338742
The Growth Inhibitory Potential and Antimetastatic Effect of Camel Urine on Breast Cancer Cells In Vitro and In Vivo
Firdaus Romli, MSc,1 Nadiah Abu, PhD,1 Faten A. Khorshid, PhD,2 Syed Umar Faruq Syed Najmuddin, MSc,1 Yeap Swee Keong, PhD,1 Nurul Elyani Mohamad, PhD,1 Muhajir Hamid, PhD,1 Noorjahan Banu Alitheen, PhD,1 and Nik Mohd Afizan Nik Abd Rahman, PhD
Although it may sound unpleasant, camel urine has been consumed extensively for years in the Middle East as it is believed to be able to treat a wide range of diseases such as fever, cold, or even cancer. People usually take it by mixing small drops with camel milk or take it directly. The project aims to study the effects of camel urine in inhibiting the growth potential and metastatic ability of 4T1 cancer cell line in vitro and in vivo.
In order to fully establish camel urine’s potential, an in vivo study was carried out by treating mice inoculated with 4T1 cells with 2 different doses of camel urine. By the end of the treatment period, the tumor in both treated groups had reduced in size as compared to the control group. Additional assays such as the TUNEL assay, immunophenotyping, cytokine level detection assay, clonogenic assay, and proteome profiler demonstrated the capability of camel urine to reduce and inhibit the metastatic potential of 4T1 cells in vivo. To sum up, further study of anticancer properties of camel urine is justified, as evidenced through the in vitro and in vivo studies carried out. Better results were obtained at higher concentration of camel urine used in vivo. Apart from that, this project has laid out the mechanisms employed by the substance to inhibit the growth and the metastatic process of the 4T1 cell.